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The predominant cause of coronary artery disease is elevated levels of abnormal lipoproteins(cholesterol) due to a less than ideal cholesterol lipoprotein metabolism which deposits cholesterol crystals into the arteries. It can be rapidly or slowly progressive and occasionally manifests itself in 20 and 30-year-olds but usually is reserved for the 50 and 60-year-olds in men and 10 years later in women.

Most people over 40 and many in their 30s and 20s have coronary artery disease, are not aware of it and think they are completely healthy. One can have minimal or a 90% narrowing of one of the coronary arteries and be asymptomatic even with exercise, especially if one has developed collaterals (new blood vessels from a non-occluded artery from another area of the heart to the area of the heart with a narrowed blood vessel). Over 80% of individuals over 65 have significant coronary artery disease. The treatment of asymptomatic coronary artery disease is medical therapy. The ideal situation is to treat the factors that cause the coronary artery disease years before it is allowed to progress to this stage. That is the mission of CVRRUSA.

When a person becomes symptomatic from coronary artery disease(angina, heart attack, acute coronary syndrome even or even silent ischemia) they now have ischemic heart disease associated with coronary artery disease. In these conditions the heart is being acutely or chronically starved for blood. so in one instant one can go from normal to having a heart condition. That simply is not true, the groundwork for this disease had been laid years before.

The best treatment for this problem would have been to prevent the coronary artery disease initially. That is the mission of CVRRUSA. Contact Us

When we are born, there is one layer of endothelium(cell lining) of our arteries as is illustrated in the top half of the lower part of this cartoon arterial diagram.  As we get older and by the age of 20, our arteries can become one of a continuum of thicknesses( green circle) as indicated around the circumference of the lower cartoon half.  The variation depends upon the genetic makeup of our body, diet and exercise.  If we all could stay at these stages, there would be very few heart attacks. The goal of The Road Map is to maintain our arteries at this stage.

By middle-aged, most of our arterial tree looks like this second diagram, the yellow area (appropriately named the vulnerable plaque).  What may not be  obvious is that the lumen (blood flow area) is relatively maintained because of a phenomenon called positive remodeling (the wall next to the plaque gives way and expands).

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Thin shoulder(dangerous) Intimal Lining

Macrophages eroding intima

Thick(safer) Intimal Lining

Large Necrotic Lipid Core

Variable Intimal thickening

Normal lining or intima

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